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- Title
Investigation of cytokine polymorphisms on viral infections after renal transplantation exhibit association between IFN‐γ +874 A > T and CMV manifestations.
- Authors
de Almeida, Stéphanie Gomes Santos; Knakcfuss, Fabiana Batalha; Assis, Lívia Maria; de Sousa, Regina Celia Gonçalves; Matuck, Tereza Azevedo; de Carvalho, Deise de Boni Monteiro; Machado, Ricardo Luiz Dantas; Guimarães, Maria Angelica Arpon Marandino; Varella, Rafael Brandão
- Abstract
We investigated the effects of TNF‐α, IFN‐γ, IL‐10 polymorphisms on viral infections (CMV, BKPyV, HHV‐6, EBV) after renal transplantation. IFN‐γ+874 A > T (lower IFN production) was associated with CMV disease (p =.039) in patients under mycophenolate‐based therapy and graft failure (p =.025). This study underscores the role of IFN‐γ+874 SNP in CMV infection.
- Subjects
KIDNEY transplantation; VIRUS diseases; CYTOKINES; CYTOMEGALOVIRUS diseases; EPSTEIN-Barr virus; CYTOMEGALOVIRUSES; INTERLEUKIN-10
- Publication
International Journal of Immunogenetics, 2022, Vol 49, Issue 6, p379
- ISSN
1744-3121
- Publication type
Article
- DOI
10.1111/iji.12601