We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Single nucleotide polymorphisms of TNFAIP3 are associated with systemic lupus erythematosus in Han Chinese population.
- Authors
Han, J.‐W.; Wang, Y.; Li, H.‐B.; Alateng, C.; Bai, Y.‐H.; Sun, Z.‐Q.; Lv, X.‐X.; Wu, R.‐N.
- Abstract
The polymorphisms of tumour necrosis factor alpha-induced protein 3 ( TNFAIP3) have been found to associate with several autoimmune diseases. This study aimed to explore the association of single nucleotide polymorphisms ( SNPs) of TNFAIP3 gene with systemic lupus erythematosus ( SLE) in Han Chinese. Thirty-two SNPs were genotyped in 284 patients with SLE and 630 controls using the ligation detection reaction ( LDR) method. The quality control steps and statistical analyses were performed using the plink 1.07 package and haploview software. We found that 13 SNPs in TNFAIP3 showed significant association with SLE ( P < 1.85 × 10−3), and all of them were in high linkage disequilibrium ( LD). After conditioning on the SNP rs2230926, other 12 SNPs did not show association ( P > 0.27). All 13 SNPs showed most significant association in the dominant model. In haplotype analysis, a long risk SNP haplotype ( GCCCGTGTCATGG) showed most significant association ( P = 1.00 × 10−4). In conclusion, our data suggest that TNFAIP3 is a susceptible gene for SLE in the Han Chinese population.
- Subjects
SINGLE nucleotide polymorphisms; SYSTEMIC lupus erythematosus; TUMOR necrosis factors; PROTEIN research; QUALITY control; AUTOIMMUNE diseases
- Publication
International Journal of Immunogenetics, 2016, Vol 43, Issue 2, p96
- ISSN
1744-3121
- Publication type
Article
- DOI
10.1111/iji.12250