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- Title
Chiral Phase Transfer Catalysts for the Synthesis of Chiral N-Heterocycles via.
- Authors
Tiso, Silvia; Massa, Antonio
- Abstract
The effectiveness of a series of chiral phase transfer catalysts in of active methylene compounds with 2-cyanobenzaldehyde leading to chiral 3-substituted isoindolinones and fused benzoindolizidinones has been investigated. High yields and moderate enantiomeric excesses (e.e.s) were achieved employing a chiral phase-transfer catalyst derived from bifunctional urea-quinine. Moreover, an efficient process of heterochiral crystallization, performed on moderately enantioenriched compounds, led to an impressive increase of the enantiopurity up to 93% e.e.s.
- Subjects
HETEROCYCLIC compounds synthesis; ENANTIOSELECTIVE catalysis; CATALYSTS; CHEMICAL inhibitors; CATALYMETRIC titration
- Publication
Journal of Heterocyclic Chemistry, 2015, Vol 52, Issue 5, p1570
- ISSN
0022-152X
- Publication type
Other
- DOI
10.1002/jhet.2170