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- Title
Synthesis of 1-(Cyclohexylamino)-2-(aryl)pyrrolo[1,2-a]quinoline-3-carbonitrile Derivatives Using a Mild, Four-Component Reaction.
- Authors
Maghsoodlou, Malek Taher; Hazeri, Nourallah; Khandan ‐ Barani, Khatereh; Habibi ‐ Khorasani, Sayyed Mostafa; Abedi, Alireza
- Abstract
1-(Cyclohexylamino)-2-(aryl)pyrrolo[1,2-a]quinoline-3-carbonitrile derivatives were synthesized in an efficient method from four-component between cyclohexyl isocyanide, quinoline, malononitrile, and aromatic aldehydes in the presence of a catalytic amount of titanium dioxide (TiO2) in CH2Cl2 at ambient temperature in good yields. Silica gel column chromatography was employed for HCN elimination and then 1, 3 hydrogen shift was led to form final products 5a, 5b, 5c, 5d, 5e.
- Subjects
AMINO compound synthesis; CARBONITRILES; ISOCYANIDES; QUINOLINE; MALONONITRILE; AROMATIC aldehydes
- Publication
Journal of Heterocyclic Chemistry, 2014, Vol 51, pE152
- ISSN
0022-152X
- Publication type
Article
- DOI
10.1002/jhet.1913