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- Title
Anti-obesity effect of Neoagaro-oligosaccharides with overweight and obese subjects: a 16-week, randomized, double-blind, placebo-controlled clinical trial.
- Authors
Baek, Hyang-Im; Ha, Ki-Chan; Park, Yu Kyung; Lee, Je Hyeon; Kim, Eun Joo; Ko, Hye-Jeong; Joo, Jong Cheon
- Abstract
Background: This trial aimed to evaluate the anti-obesity effects and safety of Neoagaro-oligosaccharides (NAOs) in humans in a 16 week, randomized, double-blind, placebo-controlled clinical trial. Methods: One hundred overweight or obese subjects with a body mass index of 23 to 34.9 kg/m2 and a percent body fat of > 25% for males or > 30% for females were enrolled. NAOs or placebo products were administered at 3 g (twice a day, four capsules once) each for 16 weeks. Efficacy and safety biomarkers were measured before and after intervention. Results: After 16 weeks of intervention, the group administered with NAOs had statistically significant decreases in visceral fat area and visceral-subcutaneous fat area ratio compared to the placebo group. The NAOs group suppressed the increase in weight and BMI compared to the placebo group, which was significant between groups. High-density lipoprotein- cholesterol was increased in the group administered with NAOs, which showed a significant trend compared to the placebo group. Clinical changes were not observed for any safety biomarkers. Conclusions: These results suggest that NAOs have a beneficial effect on obesity. Thus, NAOs could be used as an anti-obesity supplement without side effects. Trial registration: cris.nih.go.kr: (KCT0006640, 07/10/2021).
- Subjects
PREVENTION of obesity; OBESITY; BIOMARKERS; FOOD consumption; PLACEBOS; RANDOMIZED controlled trials; PHYSICAL activity; T-test (Statistics); BLIND experiment; DESCRIPTIVE statistics; CHI-squared test; RESEARCH funding; BODY mass index; HIGH density lipoproteins; STATISTICAL sampling; ANTIOBESITY agents; PATIENT safety
- Publication
BMC Complementary Medicine & Therapies, 2023, Vol 23, Issue 1, p1
- ISSN
2662-7671
- Publication type
Article
- DOI
10.1186/s12906-023-04206-2