We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A simplified modification to rapidly determine the residues of nitrofurans and their metabolites in aquatic animals by HPLC triple quadrupole mass spectrometry.
- Authors
Ryu, EunChae; Park, Ji-Sung; Giri, Sib Sankar; Park, Se Chang
- Abstract
A simplified method is described for reducing the analysis time of nitrofurans (NFs) and nitrofuran metabolites (NFMs) in the aquatic animals. Most existing HPLC-MS/MS methods are intended only for NFMs and are based on their fast metabolic transformations. We optimized a method for simultaneously detecting major NFs and their metabolites, including nitrovin (NV) that imply use of an optimized buffer solution. The novel method was validated by six different aquatic animal matrices (loach, catfish, shrimp, lobster, scallop, and eel) spiked with the analytes at 0.5, 1.0, and 2.0 μg kg−1. Recovery rates and %RSDs (relative standard deviations) of 82–97% and 1–8% were observed for NFMs, respectively, with values of 70–96% and 1–8% obtained for furazolidone, furaltadone, nitrofurazone, nitrofurantoin, and NV, respectively. Linearity was observed in the 0.1–20 μg L−1 range, with correlation coefficients greater than 0.99 recorded for all compounds. The developed method is sensitive, accurate, easier to use, and faster than previous methods when applied to real samples. To the best of our knowledge, this is the first method that can simultaneously determine NFs and their metabolites, as well as NV, using a single-step extraction process.
- Subjects
AQUATIC animals; QUADRUPOLE ion trap mass spectrometry; MASS spectrometry; HIGH performance liquid chromatography; NITROFURANS; METABOLITES
- Publication
Environmental Science & Pollution Research, 2021, Vol 28, Issue 6, p7551
- ISSN
0944-1344
- Publication type
Article
- DOI
10.1007/s11356-020-11074-7