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- Title
Cytoskeleton-modulating effectors of enteropathogenic and enterohemorrhagic Escherichia coli: a case for EspB as an intrinsically less-ordered effector.
- Authors
Hamada, Daizo; Hamaguchi, Mitsuhide; Suzuki, Kayo N.; Sakata, Ikuhiro; Yanagihara, Itaru
- Abstract
Enterohemorrhagic and enteropathogenic Escherichia coli produce various effector proteins that are directly injected into the host-cell cytosol through the type III secretion system. E. coli secreted protein (Esp)B is one such effector protein, and affects host-cell morphology by reorganizing actin networks. Unlike most globular proteins that have well-ordered, rigid structures, the structures of type III secretion system effectors from pathogenic Gram-negative bacteria, including EspB, are often less well-ordered. This minireview focuses on the functional relationship between the structural properties of these proteins and their roles in type III secretion system-associated pathogenesis.
- Subjects
ESCHERICHIA coli; ENTEROBACTERIACEAE; BIOLOGICAL transport; GRAM-negative bacteria; FOODBORNE diseases
- Publication
FEBS Journal, 2010, Vol 277, Issue 11, p2409
- ISSN
1742-464X
- Publication type
Article
- DOI
10.1111/j.1742-4658.2010.07655.x