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- Title
Calcium signalling by nicotinic acid adenine dinucleotide phosphate (NAADP).
- Authors
Yamasaki, Michiko; Churchill, Grant C.; Galione, Antony
- Abstract
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a recently described Ca2+ mobilizing messenger, and probably the most potent. We briefly review its unique properties as a Ca2+ mobilizing agent. We present arguments for its action in targeting acidic calcium stores rather than the endoplasmic reticulum. Finally, we discuss possible biosynthetic pathways for NAADP in cells and candidates for its target Ca2+ release channel, which has eluded identification so far.
- Subjects
NAD (Coenzyme); ADENINE; COENZYMES; NICOTINAMIDE; PYRIDINE nucleotides; NAD(P)H dehydrogenases; DEHYDROGENASES; PHOSPHATES
- Publication
FEBS Journal, 2005, Vol 272, Issue 18, p4598
- ISSN
1742-464X
- Publication type
Article
- DOI
10.1111/j.1742-4658.2005.04860.x