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- Title
Glutamate receptor ion channels: where do all the calories go?
- Authors
Mayer, Mark L.
- Abstract
In this article, the author discusses the study by A.Y. Lau and B. Roux regarding the application of a comprehensive set of all-atom molecular dynamics simulations in the legal binding. The author mentions that the approach enable them to determine that the glutamate binding is unfavorable into the ligand-binding domain. He adds that the study of Lau and Roux was of great importance to understand the activation of ligand-gated ion channels through neurotransmitters binding.
- Subjects
MOLECULAR dynamics; ION channels; BINDING energy; GLUTAMIC acid; NEUROTRANSMITTERS; LAU, A. Y.; ROUX, B.
- Publication
Nature Structural & Molecular Biology, 2011, Vol 18, Issue 3, p253
- ISSN
1545-9993
- Publication type
Opinion
- DOI
10.1038/nsmb0311-253