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- Title
Structure of the calcium-rich signature domain of human thrombospondin-2.
- Authors
Carlson, C Britt; Bernstein, Douglas A; Annis, Douglas S; Misenheimer, Tina M; Hannah, Blue-leaf A; Mosher, Deane F; Keck, James L
- Abstract
Thrombospondins (THBSs) are secreted glycoproteins that have key roles in interactions between cells and the extracellular matrix. Here, we describe the 2.6-Å-resolution crystal structure of the glycosylated signature domain of human THBS2, which includes three epidermal growth factor–like modules, 13 aspartate-rich repeats and a lectin-like module. These elements interact extensively to form three structural regions termed the stalk, wire and globe. The THBS2 signature domain is stabilized by these interactions and by a network of 30 bound Ca2+ ions and 18 disulfide bonds. The structure suggests how genetic alterations of THBSs result in disease.
- Subjects
THROMBOSPONDINS; GLYCOPROTEINS; CELL communication; GROWTH factors; PROTEOMICS; GENETICS
- Publication
Nature Structural & Molecular Biology, 2005, Vol 12, Issue 10, p910
- ISSN
1545-9993
- Publication type
Article
- DOI
10.1038/nsmb997