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- Title
Enantioselective Copper(II)-Catalyzed Conjugate Addition of Indoles to β -Substituted Unsaturated Acyl Phosphonates.
- Authors
Ma, Hong ‐ Li; Xie, Lei; Zhang, ZhenHua; Li, Jia ‐ Qi; Qin, Zhao ‐ Hai; Fu, Bin
- Abstract
The first copper-catalyzed enantioselective conjugate addition of indoles to β-substituted unsaturated acyl phosphonates was successfully realized by using a heteroarylidene-tethered bis(oxazoline) ligand. The reaction features high efficiency, cheap catalyst and broad generality. In the case of either β-alkyl- or β-aryl-substituted unsaturated acyl phosphonates, the 3-indolyl adducts were achieved in high yields with good to excellent enantioselectivities (up to 97% ee). The 3-indolyl adducts can serve as important intermediates in the synthesis of indole alkaloids.
- Subjects
CONJUGATE addition reactions; COPPER research; INDOLE compounds; ENANTIOSELECTIVE catalysis; BIOMOLECULES; ALKENES
- Publication
Advanced Synthesis & Catalysis, 2016, Vol 358, Issue 7, p1011
- ISSN
1615-4150
- Publication type
Article
- DOI
10.1002/adsc.201500923