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- Title
Inside Back Cover: Synthesis of 3,3-Disubstituted Oxindoles Containing a 3-(4-Aminobut-2-ynyl) Unit via Domino Heck-Sonogashira Reaction in Water (Adv. Synth. Catal. 3/2016).
- Authors
Wang, Dong ‐ Chao; Wang, Hai ‐ Xia; Hao, Er ‐ Jun; Jiang, Xiao ‐ Han; Xie, Ming ‐ Sheng; Qu, Gui ‐ Rong; Guo, Hai ‐ Ming
- Abstract
The cover picture, provided by Hai ‐ Ming Guo, Gui ‐ Rong Qu and co ‐ workers, illustrates a palladium ‐ catalyzed domino HeckSonogashira process in water. Using this strategy, a series of 3 ‐ (4 ‐ aminobut ‐ 2ynyl)oxindole derivatives with an all ‐ carbon quaternary center at the 3 ‐ position was easily synthesized. The reactions provided products in excellent yields with a broad substrate tolerance. The target product was readily converted into a pharmaceutically active molecule, which is used as a 5 ‐ HT7 receptor antagonist. Details can be found in the Update on pages 494 – 499 (D. ‐ C. Wang, H. ‐ X. Wang, E. ‐ J. Hao, X. ‐ H. Jiang, M. ‐ S. Xie, G. ‐ R. Qu, H. ‐ M. Guo, Adv. Synth. Catal. 2016, 358, 494 – 499; DOI: 10.1002/adsc.201500887).
- Subjects
OXINDOLES; INDOLINE
- Publication
Advanced Synthesis & Catalysis, 2016, Vol 358, Issue 3, p500
- ISSN
1615-4150
- Publication type
Article
- DOI
10.1002/adsc.201500887