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- Title
Synthesis of 3,4-Fused 2-Quinolones from an ( ortho-Aminophenyl)propiolate via Sequential Cycloaddition/Lactam Formation.
- Authors
Murayama, Tsukasa; Shibuya, Masatoshi; Yamamoto, Yoshihiko
- Abstract
An N-phthalimide-protected ( ortho-aminophenyl)propiolate was prepared by the carboxylation of the corresponding silylalkyne precursor with carbon dioxide. The obtained propiolate was further transformed to various 3,4-fused 2-quinolones via cycloadditions and subsequent deprotection/lactam formation.
- Subjects
QUINOLONE antibacterial agents synthesis; RING formation (Chemistry); LACTAMS; PHTHALIMIDES; NITROGEN compounds
- Publication
Advanced Synthesis & Catalysis, 2015, Vol 357, Issue 4, p690
- ISSN
1615-4150
- Publication type
Article
- DOI
10.1002/adsc.201401069