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- Title
Stereotactic radiation therapy for progressive residual pilocytic astrocytomas.
- Authors
Lizarraga, Karlo; Gorgulho, Alessandra; Lee, Steve; Rauscher, Glenn; Selch, Michael; DeSalles, Antonio
- Abstract
This report shows the results of stereotactic radiation therapy for progressive residual pilocytic astrocytomas. Medical records of patients who had undergone stereotactic radiation therapy for a progressive residual pilocytic astrocytoma were reviewed. Between 1995 and 2010, 12 patients with progression of a residual pilocytic astrocytoma underwent stereotactic radiation therapy at UCLA. Presentation was headache (4), visual defects (3), hormonal disturbances (2), gelastic seizures (2) and ataxia (1). MRI showed a cystic (9), mixed solid/cystic ( 2) or solid tumor (1); located in the hypothalamus (5), midbrain (3), thalamus (2), optic chiasm (1) or deep cerebellum (1). Median age was 21 years (range 5-41). Nine tumors received stereotactic radiotherapy (SRT). Three tumors received stereotactic radiosurgery (SRS), two of them to their choline positive regions. SRT median total dose was 50.4 Gy (40-50.4 Gy) in a median of 28 fractions (20-28), using a median fraction dose of 1.8 Gy (1.8-2 Gy) to a median target volume of 6.5 cm. (2.4-33.57 cm) SRS median dose was 18.75 Gy (16.66-20 Gy) to a median target volume of 1.69 cm (0.74-2.22 cm). Median follow-up time was 37.5 months. Actuarial long-term progression-free and disease-specific survival probabilities were 73.3 and 91.7 %, respectively. No radiation-induced complications were observed. Stereotactic radiation therapy is a safe and effective modality to control progressive residual pilocytic astrocytomas. Better outcomes are obtained with SRT to entire tumor volumes than with SRS targeting choline positive tumor regions.
- Subjects
ASTROCYTOMAS; STEREOTAXIC techniques; CANCER radiotherapy; RADIOSURGERY; FOLLOW-up studies (Medicine); RADIATION doses; MEDICAL records; THERAPEUTICS
- Publication
Journal of Neuro-Oncology, 2012, Vol 109, Issue 1, p129
- ISSN
0167-594X
- Publication type
Article
- DOI
10.1007/s11060-012-0877-5