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- Title
The Baylis–HillmanAdducts as Valuable Source for OnePot MultiStep Synthesis: A Facile Synthesis of Substituted Piperidin2ones.
- Authors
Deevi Basavaiah; RajuJannapu Reddy; DandamudiV. Lenin
- Abstract
A facile, convenient, and onepot multistep synthesis of substituted piperidin2ones from the Baylis–Hillmanalcohols derived from various aldehydes and acrylonitrile, involving Johnson–Claisenrearrangement, reduction of an α,βunsaturated nitrile moiety into the saturated amineskeleton, followed by cyclization, in an operationally simple procedure, is described.
- Subjects
ORGANIC synthesis; PIPERIDINE; SUBSTITUTION reactions; ALCOHOLS (Chemical class); ALDEHYDES; ACRYLONITRILE; CLAISEN rearrangement; CHEMICAL reduction
- Publication
Helvetica Chimica Acta, 2010, Vol 93, Issue 6, p1180
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.200900352