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- Title
Spatially Resolved Derivatization of Solid-Phase-Synthesis Beads with Fluorescent Dendrimers: Creation of Localized Microdomains.
- Authors
Cardona, Claudia M.; Jannach, Stephan H.; Huang, Hao; Itojima, Yukiko; Leblanc, Roger M.; Gawley, Robert E.; Baker, Gary A.; Brauns, Eric B.
- Abstract
Second and third generation Newkome-type trifurcated dendrimers, containing either a coumarin or dansyl fluorescent probe at the dendrimer core, have been synthesized and attached to ArgoGel ® solid-phase-synthesis beads. Subsequent reaction with rhodamine dye shows that the dye can penetrate throughout the beads to acylate the remaining sites. Thus, it is possible to achieve a spatially resolved microdomain for library formation at the core of the dendrimer, primarily on the bead's periphery, and a second microdomain suitable for derivatization by other reagents such as encoding tags and fluorescent sensors.
- Publication
Helvetica Chimica Acta, 2002, Vol 85, Issue 10, p3532
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/1522-2675(200210)85:10<3532::AID-HLCA3532>3.0.CO;2-F