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- Title
A Convenient Synthesis of Aryl-Substituted N-Carbamoyl/ N-Thiocarbamoyl Narcotine and Related Compounds.
- Authors
Aggarwal, Shefali; Ghosh, Narendra N.; Aneja, Ritu; Joshi, Harish; Chandra, Ramesh
- Abstract
The reaction of nornarcotine and 5-bromonornarcotine, synthesized from noscapine, with suitable aromatic isocyanates or isothiocyanates provides a general method for the synthesis of aryl-substituted N-carbamoyl or N-thiocarbamoylnarcotine and related compounds. Similarly, 15a has been prepared via the reduction of the lactone ring moiety of noscapine. Also, an improved procedure, which utilizes narcotine N-oxide⋅HCl for generation of nornarcotine, is described.
- Publication
Helvetica Chimica Acta, 2002, Vol 85, Issue 8, p2458
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/1522-2675(200208)85:8<2458::AID-HLCA2458>3.0.CO;2-L