We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Neurotoxic Sesquiterpenoids from the Yellow Star Thistle Centaurea solstitialis L. (Asteraceae).
- Authors
Wang, Ying; Hamburger, Matthias; Cheng, Celine H. K.; Costall, Brenda; Naylor, Robert J.; Jenner, Peter; Hostettmann, Kurt
- Abstract
Ingestion of yellow star thistle ( Centaurea solstitialis L.) by horses produces parkinsonism due to nigro-pallidal degeneration. The toxin responsible has not been identified so far. A CH2Cl2 extract from the aerial parts of C. solstitialis exhibited significant neurotoxicity against primary neuronal cultures of foetal rat brain. Activity-guided fractionation yielded the known sesquiterpene lactones solstitialin A ( 1), 13- 0-acetylsolstitialin A ( 3), cynaropicrin ( 4), and the hitherto unknown 3- O-acetylsolstitialin A ( 2). In the bioassay with rat foetal full cell culture, 3 and 4 were toxic in a concentration-dependent manner and may be responsible for the ability of the plant to cause neurodegenerative changes in the brain of horses.
- Publication
Helvetica Chimica Acta, 1991, Vol 74, Issue 1, p117
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.19910740114