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- Title
Theoretical study of the hydroxylation of phenols mediated by an end-on bound superoxo–copper(II) complex.
- Authors
Güell, Mireia; Luis, Josep M.; Siegbahn, Per E. M.; Solà, Miquel
- Abstract
Peptidylglycine α-amidating monooxygenase and dopamine β-monooxygenase are copper-containing proteins which catalyze essential hydroxylation reactions in biological systems. There are several possible mechanisms for the reductive O2-activation at their mononuclear copper active site. Recently, Karlin and coworkers reported on the reactivity of a copper(II)–superoxo complex which is capable of inducing the hydroxylation of phenols with incorporated oxygen atoms derived from the Cu(II)-O2·− moiety. In the present work the reaction mechanism for the abovementioned superoxo complex with phenols is studied. The pathways found are analyzed with the aim of providing some insight into the nature of the chemical and biological copper-promoted oxidative processes with 1:1 Cu(I)/O2-derived species.
- Subjects
AROMATIC compounds; CHEMICAL reactions; HYDROXYLATION; PHOTOSYNTHETIC oxygen evolution; SYSTEMS theory; PHENOL
- Publication
Journal of Biological Inorganic Chemistry (JBIC), 2009, Vol 14, Issue 2, p273
- ISSN
0949-8257
- Publication type
Article
- DOI
10.1007/s00775-008-0447-7