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- Title
Origin of sympathetic and sensory innervation of the endolymphatic sac. A retrograde axonal tracing study in the guinea pig.
- Authors
Birgersson, Lena; Friberg, Ulla; Rask-Andersen, Helge; Erwall, Claes; Widenfalk, Bertil; Birgersson, L; Friberg, U; Rask-Andersen, H; Erwall, C; Widenfalk, B
- Abstract
Lectin-conjugated horseradish peroxidase (WGA-HRP) was used as a retrograde axonal tracer to determine endolymphatic sac (ES) innervation and the nature of such a nervous supply. WGA-HRP placed into the ES of the guinea pig resulted in labelling of neurons in the ipsilateral sympathetic superior cervical ganglion and the sensory trigeminal ganglion. The number of labelled neurons in the cervical superior ganglion varied according to the survival time with peak labelling occurring after 48 h. Sparse labelling of the sensory trigeminal ganglion was also present after 48 h. The results indicate that sympathetic neurons from the superior cervical ganglion and to a certain extent trigeminal somatosensory neurons innervate the ES or perisaccular tissue. If these findings reflect the existence of a sympathetic functional reflex unit remains to be elucidated.
- Subjects
ANIMAL experimentation; AUTONOMIC ganglia; COMPARATIVE studies; SENSORY ganglia; GUINEA pigs; RESEARCH methodology; MEDICAL cooperation; OXIDOREDUCTASES; RESEARCH; SENSORY neurons; SYMPATHETIC nervous system; EVALUATION research; ENDOLYMPHATIC sac; INNERVATION
- Publication
ORL, 1992, Vol 54, Issue 4, p188
- ISSN
0301-1569
- Publication type
journal article
- DOI
10.1159/000276296