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- Title
Cytotoxic Activity of Schisandrolic and Isoschisandrolic Acids Involves Induction of Apoptosis.
- Authors
Ze Tian; Lijia Xu; Sibao Chen; Liang Zhou; Mengsu Yang; Shilin Chen; Peigen Xiao; Erxi Wu
- Abstract
Cycloartane triterpenoid schisandrolic acid and isoschisandrolic acid were isolated from Schisandra propinqua (Wall.) Baill (Schisandraceae). Their cytotoxicity was evaluated in several cancer cell lines and primary cultured normal mouse hepatocytes. The two triterpenoids showed moderate cytotoxic activity on all tested cell lines. Fluorescence staining and cell cycle analyses were employed to elucidate the primary mechanisms of their cytotoxicity. Our results showed that two triterpenoids exerted their cytotoxic activity via G0/G1 arrest and subsequent apoptosis. Furthermore, proteolytic cleavage of poly-ADP-ribose polymerase (PARP), substrate of the caspase family, was detected and associated with apoptosis in HepG2 cells induced by the two compounds. Copyright © 2007 S. Karger AG, Basel
- Subjects
APOPTOSIS; LIVER cells; LABORATORY mice; CELL cycle; SCHISANDRA
- Publication
Chemotherapy (0009-3157), 2007, Vol 53, Issue 4, p257
- ISSN
0009-3157
- Publication type
Article
- DOI
10.1159/000102582