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- Title
Time-Kill Studies of Antimicrobial Combinations Including Cefotaxime, Ceftriaxone, Vancomycin and Meropenem against Cephalosporin-Resistant Streptococcus pneumoniae.
- Authors
Kim, Baek-Nam; Woo, Jun-Hee; Kim, Yang-Su; Ryu, Jiso; Kim, Mi-Na; Pai, Chik Hyun
- Abstract
Background: Resistance of Streptococcus pneumoniae to penicillin is now widespread and rapidly increasing all over the world. This has led to the critical need for alternative antimicrobial therapy. Methods: To assess the activities of antimicrobial combinations, including cefotaxime, ceftriaxone, vancomycin and meropenem, time-kill studies were conducted against five strains of penicillin- and cephalosporin-resistant S. pneumoniae at clinically achievable antimicrobial concentrations in cerebrospinal fluid. Results: Combinations of an extended-spectrum cephalosporin with vancomycin were not synergistic. Meropenem had a comparable bactericidal activity to those combinations, and its killing activity was not affected by the addition of cefotaxime, ceftriaxone or vancomycin. Conclusions: It is suggested that meropenem could be an effective alternative for the treatment of penicillin- and cephalosporin-resistant pneumococcal meningitis. However, more clinical data are required before it can be recommended as an effective antimicrobial agent for such cases. Copyright © 2000 S. Karger AG, Basel
- Publication
Chemotherapy (0009-3157), 2000, Vol 46, Issue 5, p303
- ISSN
0009-3157
- Publication type
Article
- DOI
10.1159/000007302