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- Title
Genomic alterations and diagnosis of renal cancer.
- Authors
Zhang, Xingming; Bolck, Hella A.; Rupp, Niels J.; Moch, Holger
- Abstract
The application of molecular profiling has made substantial impact on the classification of urogenital tumors. Therefore, the 2022 World Health Organization incorporated the concept of molecularly defined renal tumor entities into its classification, including succinate dehydrogenase–deficient renal cell carcinoma (RCC), FH-deficient RCC, TFE3-rearranged RCC, TFEB-altered RCC, ALK-rearranged RCC, ELOC-mutated RCC, and renal medullary RCC, which are characterized by SMARCB1-deficiency. This review aims to provide an overview of the most important molecular alterations in renal cancer, with a specific focus on the diagnostic value of characteristic genomic aberrations, their chromosomal localization, and associations with renal tumor subtypes. It may not yet be the time to completely shift to a molecular RCC classification, but undoubtedly, the application of molecular profiling will enhance the accuracy of renal cancer diagnosis, and ultimately guide personalized treatment strategies for patients.
- Subjects
WORLD Health Organization; RENAL cancer; RENAL cell carcinoma; CANCER diagnosis; KIDNEY tumors; TUMOR classification
- Publication
Virchows Archiv: European Journal of Pathology, 2024, Vol 484, Issue 2, p323
- ISSN
0945-6317
- Publication type
Article
- DOI
10.1007/s00428-023-03700-9