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- Title
Circulating 1,25-Dihydroxycholecalciferol After Intravenous Injections of lα-Hydroxycholecalciferol in Patients on Regular Haemodialysis.
- Authors
Papapoulos, S. E.; Berg, H. v.d.; Frölich, M.; Valentijn, R. M.
- Abstract
The formation of 1.25-dihydroxycholecalciferol (1.25-(OH)D after single intravenous injections of 1α-hydroxycholecalciferol (1α-OHD) was examined in four patients with chronic renal failure on regular haemodialysis. Following 1–3μg 1α-OHD administered at weekly intervals, 1.25-(OH)D appeared in the circulation within 1 h, and peak concentrations were reached between 2 h and 5 h. By 8 h serum 1.25-(OH)D concentrations had started declining and by 44 h they had returned to baseline after 1μg 1α-OHD but they were still above basal after 2 and 3 μg by an average of 30 pmol/l. One week after injections, concentrations were back to basal in all patients studied. The serum 1,25-(OH)D dose response to injected la-OHD was linear, indicating ample capacity of the liver 25-hydroxylase to further hydroxylate 1α-OHD. However, examination of the individual responses revealed lower increments in serum 1.25-(OH) concentrations in the patients with the highest basal serum 25-hydroxyvitamin D concen trations. Intravenous 1α-OHD may be useful in the further study of the interactions between 1.25-(OH) calcium and PTH in chronic renal failure, as well as of the hepatic metabolism of vitamin D.
- Publication
Nephrology Dialysis Transplantation, 1988, Vol 3, Issue 5, p647
- ISSN
0931-0509
- Publication type
Article