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- Title
In vitro and in vivo Effects of Vardenafil (a PDE-5 Inhibitor) on Corpus Cavernosal Smooth Muscle Relaxation in Diabetic Rabbits.
- Authors
Lau, D. H. W.; Mumtaz, F. H.; Mikhailidis, D. P.; Thompson, C. S.
- Abstract
Introduction: Diabetes mellitus is associated with impaired cavernosal smooth muscle relaxation (CSMR) and the development of erectile dysfunction (ED). Vardenafil, a phosphodiesterase type 5 inhibitor has been used to treat ED. The aim of this study was to assess the in vitro and in vivo effects of vardenafil on diabetic rabbit CSMR. Methods: Organ bath studies were used. Results: Sodium nitroprusside (SNP)- and electrical field stimulation (EFS)-induced CSMR in diabetic rabbits given the vehicle was significantly impaired when compared with controls. The in vitro addition of vardenafil significantly enhanced SNP-induced CSMR in diabetic animals given the vehicle. SNP-induced CSMR in diabetic animals given in vivo vardenafil was significantly increased when compared with the diabetic untreated group. The in vitro addition of vardenafil significantly enhanced SNP and EFS-induced CSMR in cavernosal tissue taken from diabetic animals given vardenafil in vivo. Conclusions: The present findings suggest that the combination of in vitro and in vivo vardenafil enhance diabetic CSMR, reinforcing the use of vardenafil for the treatment of diabetes-induced ED. Copyright © 2009 S. Karger AG, Basel
- Subjects
TREATMENT of diabetes; SMOOTH muscle; IMPOTENCE; TISSUES; LABORATORY rats
- Publication
Urologia Internationalis, 2009, Vol 82, Issue 1, p101
- ISSN
0042-1138
- Publication type
Article
- DOI
10.1159/000176035