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- Title
Alpha-Fetoprotein, Carcinoembryonic Antigen, Human Chorionic Gonadotropin and Its Beta Subunit in Metastatic Choriocarcinoma.
- Authors
Gips, H.; Vahrson, H.; Bailer, P.; Korte, K.
- Abstract
Serum levels of a-fetoprotein (AFP), carcinoembryonic antigen (CEA), human chorionic gonadotropin (hCG) and its beta subunit (β-hCG) were measured during the therapy of a choriocarcinoma with lung metastases. All AFP determinations were in the normal range. The CEA levels showed a correlation with the radiologically confirmed development of lung metastases. A rise of hCG during the first 2-6 days to 177.3-407.5% of the initial level and a descent to 17.9-33.7% of the initial level at the 10th day of therapy were typical behavioral patterns associated with tumor sensitivity. The onset of tumor resistance against the chemo-therapeutic preparation used was evident within 10 days after therapy. A small rise, a slight fall below the initial value, and then a rapid increase to above the initial level were typical parameters. With established tumor resistance there was an autonomous unremitting increase of hCG activity. Short-term follow-up of hCG in intervals of 2 days at least for over a period of 10 days are deemed advisable for early detection of resistance toward the particular chemotherapeutic preparation used. Copyright © 1980 S. Karger AG, Basel
- Publication
Oncology, 1980, Vol 37, Issue 3, p157
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000225426