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- Title
Molecular look at melanoma, or glycoproteins in cells of neuroectodermal origin.
- Authors
Załugowicz, Emilia
- Abstract
For years, scientists from around the world, side by side with the health service, have been working on understanding the mechanisms of both nervous system diseases and all types of cancer, while trying to unravel the biggest mystery of how to effectively treat them. Along with the development of medicine and science, the belief that it is impossible to cure slowly begins to dominate over a single organ, e.g. the brain or skin without interfering with other parts of the human body. At the same time, we are becoming aware of the many years of work of many research teams on how tumors metastasize from one tissue and attack another, covering the entire body, and that there is more than one way to expand the body in cancer. The research presented here focuses on the analysis of very specific proteins that undergo the process of O-GlcNAcylation in the human body and show how much influence they can have on the development of genetic mutations in cells, with particular emphasis on their role in the melanocytes of the largest organ of the human body, i.e. the skin. The presented cups are also to draw attention to the fact that O-GlcNAcylated proteins present in cells of the same origin (differentiating from the neuroectoderm) may be one of the key causes of the characteristic metastases in neoplastic diseases. proteomic approach, a total of 60 O-GlcNAcylated proteins were identified, 36 of which were identified for the HEMa-LP cell line, 14 for the E076 melanoma cell line, and 10 proteins were common to both of these cell lines. These proteins have not yet been described for O-GlcNAcylation, so this is a new subset of glycoproteins that offers further research opportunities and new insight into treatment options for skin cancer and invasive tissues of the nervous system.
- Subjects
MELANOMA; GLYCOPROTEINS; CENTRAL nervous system; PROTEOMICS; MELANOCYTES
- Publication
European Journal of Translational & Clinical Medicine, 2021, Vol 4, p65
- ISSN
2657-3148
- Publication type
Article