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- Title
It doesn't take three.
- Authors
Heinrichs, Arianne
- Abstract
The article reports on the subsequent activity of ubiquitin-binding domain (UBD)-containing substrates during ubiquitylation. Research conducted by D. Hoeller and colleagues reveals that the substrates occur during the absence of E3 ligase in ubiquitylation. The loss of E3 ligases, however, did not affect monoubiquitylation in several UBD-containing proteins. The authors believe that E3-independent monoubiquitylation maintains the homeostasis forms of UBD-containing proteins in cells.
- Subjects
UBIQUITIN; CARRIER proteins; LIGASES; CYTOLOGICAL research; HOMEOSTASIS; CELLS
- Publication
Nature Reviews Molecular Cell Biology, 2007, Vol 8, Issue 8, p596
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm2232