Discusses research being done on the identification of proteins that interact with origin-recognition complex (ORC). Reference to study by Yu-Chieh Du and Bruce Stillman, published on a 2002 issue of the journal "Cell"; Number of proteins specifically precipitated from wild-type yeast whole-cell extracts; Nature of interaction between yeast Yph1 and ORC; Ribosome profile of a temperature-sensitive Yph1 mutant strain.