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- Title
Regulation of innate immune cell function by mTOR.
- Authors
Weichhart, Thomas; Hengstschläger, Markus; Linke, Monika; Hengstschläger, Markus
- Abstract
The innate immune system is central for the maintenance of tissue homeostasis and quickly responds to local or systemic perturbations by pathogenic or sterile insults. This rapid response must be metabolically supported to allow cell migration and proliferation and to enable efficient production of cytokines and lipid mediators. This Review focuses on the role of mammalian target of rapamycin (mTOR) in controlling and shaping the effector responses of innate immune cells. mTOR reconfigures cellular metabolism and regulates translation, cytokine responses, antigen presentation, macrophage polarization and cell migration. The mTOR network emerges as an integrative rheostat that couples cellular activation to the environmental and intracellular nutritional status to dictate and optimize the inflammatory response. A detailed understanding of how mTOR metabolically coordinates effector responses by myeloid cells will provide important insights into immunity in health and disease.
- Subjects
BIOLOGICAL models; CELLS; CELLULAR signal transduction; CYTOKINES; DENDRITIC cells; IMMUNITY; MACROPHAGES; RESEARCH funding
- Publication
Nature Reviews Immunology, 2015, Vol 15, Issue 10, p599
- ISSN
1474-1733
- Publication type
journal article
- DOI
10.1038/nri3901