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- Title
The impact of infection and tissue damage in solid-organ transplantation.
- Authors
Chong, Anita S.; Alegre, Maria-Luisa
- Abstract
Investigations over the past two decades are revealing complexities in the regulation of the innate immune response, and how this response, in turn, controls adaptive immunity. Microbial exposure, infections and tissue damage that accompany solid-organ transplantation result in the release of pathogen- and damage-associated molecular patterns, as well as pathogen- or allograft-derived antigens. Here, we review these triggers of innate and adaptive immunity, and discuss emerging paradigms of the many ways in which infections and tissue damage might directly or indirectly affect alloreactivity and the outcome of transplanted allografts.
- Subjects
NATURAL immunity; IMMUNE response; IMMUNITY; ANTIGENS; TRANSPLANTATION of organs, tissues, etc.
- Publication
Nature Reviews Immunology, 2012, Vol 12, Issue 6, p459
- ISSN
1474-1733
- Publication type
Article
- DOI
10.1038/nri3215