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- Title
Mucosal immunology: Germ and gene tag team.
- Authors
Bordon, Yvonne
- Abstract
The article discusses the research on the link of viral infection to Crohn's disease causation. It references the study "Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine," by K. Cadwell and colleagues in the 2010 issue of "Cell." It says that the infection triggers intestinal pathology which results to Crohn's disease ATG16L1 gene mutation. It adds that viral infection with single risk allele can modify inflammatory response.
- Subjects
CROHN'S disease; VIRUS diseases; INTESTINAL diseases; GENETIC mutation; GENES; CADWELL, K.; DISEASE risk factors
- Publication
Nature Reviews Immunology, 2010, Vol 10, Issue 8, p542
- ISSN
1474-1733
- Publication type
Article
- DOI
10.1038/nri2823