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- Title
Induced pluripotent stem cells: the new patient?
- Authors
Bellin, Milena; Marchetto, Maria C.; Gage, Fred H.; Mummery, Christine L.
- Abstract
Worldwide increases in life expectancy have been paralleled by a greater prevalence of chronic and age-associated disorders, particularly of the cardiovascular, neural and metabolic systems. This has not been met by commensurate development of new drugs and therapies, which is in part owing to the difficulty in modelling human diseases in laboratory assays or experimental animals. Patient-specific induced pluripotent stem (iPS) cells are an emerging paradigm that may address this. Reprogrammed somatic cells from patients are already applied in disease modelling, drug testing and drug discovery, thus enabling researchers to undertake studies for treating diseases 'in a dish', which was previously inconceivable.
- Subjects
INDUCED pluripotent stem cells; STEM cell culture; PROGENITOR cells; SOMATIC cells; LABORATORY animals; MEDICAL screening
- Publication
Nature Reviews Molecular Cell Biology, 2012, Vol 13, Issue 11, p713
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm3448