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- Title
Innovation: Metabolomics: the apogee of the omics trilogy.
- Authors
Patti, Gary J.; Yanes, Oscar; Siuzdak, Gary
- Abstract
Metabolites, the chemical entities that are transformed during metabolism, provide a functional readout of cellular biochemistry. With emerging technologies in mass spectrometry, thousands of metabolites can now be quantitatively measured from minimal amounts of biological material, which has thereby enabled systems-level analyses. By performing global metabolite profiling, also known as untargeted metabolomics, new discoveries linking cellular pathways to biological mechanism are being revealed and are shaping our understanding of cell biology, physiology and medicine.
- Subjects
CHEMICAL affinity; METABOLITE analysis; MASS spectrometry methodology; BIOMATERIALS; BIOLOGICAL specimen analysis; CYTOLOGICAL techniques
- Publication
Nature Reviews Molecular Cell Biology, 2012, Vol 13, Issue 4, p263
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm3314