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- Title
Comparative Study of Antibacterial Activity of Tulsi, Garlic and Commercially used Antibiotics against Bovine Bacterial Endometritis using Molecular Docking Analysis.
- Authors
Arya, Damini; Tyagi, Rashmi; Sharma, Shingini; Sharma, Mridula
- Abstract
The present study was conducted with the objective to find effective drug against bacterial bovine endometritis using Molecular docking. The antibacterial property of selected plants was studied and its comparison with conventional antibiotics was done. The plants selected for study were Tulsi and Garlic on the basis of their potent antibacterial activity. Selection of bacteria (S. aureus and E. coli) for the present study was done on the basis of most predominant bacteria causing bovine endometritis as observed in previous studies. The selected bacterial proteins were docked against the phytochemicals of plants. Vital proteins of Staphylococcus aureus are Gyrase B (3G75), FtsA (3WQU), DNA ligase (3JSN), Dehydrosqualene synthase (3TFN) and Escherichia coli are FtsZ (6UMK), DNA gyrase (1KZN) and ZapD (5DKO). The docking procedure was carried out using Autodock. It was concluded that, gentamicin (-6.95 Kcal/mol), enrofloxacin (-6.97 Kcal/mol) and Tulsi (-6.40 Kcal/mol) showed better binding affinity followed by garlic (-3.89 Kcal/mol). Apigenin, a phytoconstituent found in tulsi, demonstrated the highest binding affinity(ranging from -7.2 Kcal/mol to -9.2 Kcal/mol) of all the phytochemicals found in garlic and tulsi against the targeted proteins found in bacteria. Hence, Tulsi alone or in combination with garlic can be used for further in vivo or in vitro trials in the direction of effective drug discovery against bacterial bovine endometritis.
- Subjects
GARLIC; MOLECULAR docking; ANTIBACTERIAL agents; ENDOMETRITIS; ESCHERICHIA coli; DRUG discovery
- Publication
Indian Journal of Animal Reproduction, 2023, Vol 44, Issue 2, p69
- ISSN
0970-2997
- Publication type
Article
- DOI
10.48165/ijar.2023.44.02.13