We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Use of Omadacycline as a Component of Mycobacterium Abscessus Eradication in an Adolescent With Cystic Fibrosis.
- Authors
Tucker, Mary Kate; Droemer, Lee; Condren, Michelle
- Abstract
Lung damage caused by non-tuberculous mycobacteria (NTM) infections can be devastating to individuals that are predisposed to chronic respiratory colonization. Cystic fibrosis patients are at increased risk for diminished lung function and increased mortality from NTM pulmonary infections. Treatment regimens are often intense and prolonged. The case described in this report is of a 16-year-old male with cystic fibrosis infected with Mycobacterium abscessus who showed evidence of severe nodular pulmonary disease on chest computerized tomography. His intensive treatment phase was complicated by neutropenia and drug resistance, leading to the use of omadacycline. Because of rapid improvement clinically and on computed tomography, he was successfully treated with a modified, less intense continuation phase that included azithromycin, omadacycline, and inhaled amikacin. The patient also was switched from tezacaftor/ivacaftor to elexacaftor/tezacaftor/ivacaftor during the course of NTM treatment.
- Subjects
CYSTIC fibrosis; MYCOBACTERIUM; NODULAR disease; LUNG diseases; TEENAGERS
- Publication
Journal of Pediatric Pharmacology & Therapeutics, 2023, Vol 28, Issue 2, p172
- ISSN
1551-6776
- Publication type
Article
- DOI
10.5863/1551-6776-28.2.172