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- Title
大蒜醇提液对小鼠离体小肠平滑肌运动的影响.
- Authors
阿迪莱·艾力; 赵树林; 李璐璐; 孙小燕; 余万里; 郝智慧; 赵红琼
- Abstract
【Objective】 To explore the effect of alcohol extract from garlic on gastrointestinal motility and to understand its possible mechanism of action. 【Method】 In this experiment, the effect of alcohol extract from garlic on the motility of gastrointestinal smooth muscle in mice and its possible mechanism in vitro were monitored by biological signal processing system. 【Result】 The results showed that garlic alcohol extract with twice concentration (0.025% - 0.4%) inhibited the contraction amplitude of small intestine (P< 0.05), but the contraction tension had not changed (P> 0.05); The maximum effective concentration of garlic was 0.2% which inhibited the contraction of intestine, and the contraction amplitude was 26% ± 7% of pre-administration (P< 0.01); 0.2% garlic combined with M-receptor agonist bethanechol chloride or KCl was not significantly different from bethanechol chloride or KCl alone in contraction tension, amplitude, peak and area under curve (P> 0.05). 【Conclusion 】 The present results indicate that alcohol extract from garlic inhibits the movement of isolated small intestine in mice, moreover, this inhibition effect may not be related to the inhibition of cholinergic M-receptors and the inhibition of decreased intracellular potassium ion outflow.
- Publication
Xinjiang Agricultural Sciences, 2019, Vol 56, Issue 11, p2133
- ISSN
1001-4330
- Publication type
Article
- DOI
10.6048/j.issn.1001-4330.2019.11.020