We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Evaluation of the Putative Duplicity Effect of Novel Nutraceuticals Using Physico-Chemical and Biological In Vitro Models.
- Authors
Tihăuan, Bianca-Maria; Axinie, Mădălina; Marinaș, Ioana-Cristina; Avram, Ionela; Nicoară, Anca-Cecilia; Grădișteanu-Pîrcălăbioru, Grațiela; Dolete, Georgiana; Ivanof, Ana-Maria; Onisei, Tatiana; Cășărică, Angela; Pîrvu, Lucia
- Abstract
Nutraceuticals are experiencing a high-rise use nowadays, which is incomparable to a few years ago, due to a shift in consumers' peculiarity tendencies regarding the selection of alternatives to Western medicine, potential immunity boosters, or gut-health promoters. Nutraceuticals' compositions and actual effects should be proportional to their sought-after status, as they are perceived to be the middle ground between pharma rigor and naturally occurring actives. Therefore, the health benefits via nutrition, safe use, and reduction of potential harm should be the main focus for manufacturers. In this light, this study assess the nutritional profile (proteins, fats, fibers, caloric value, minerals) of a novel formulated nutraceutical, its physico-chemical properties, FTIR spectra, antioxidant activity, anthocyanins content, and potential hazards (heavy metals and microbiological contaminants), as well as its cytotoxicity, adherence, and invasion of bacteria on HT-29 cells, as well as its evaluation of beneficial effect, potential prebiotic value, and duplicity effect on gut microbiota in correlation with Regulation (EC) No 1924/2006. The results obtained indicate the growth stimulation of Lb. rhamnosus and the inhibitory effects of E.coli, Ent. Faecalis and Lc. lactis. The interaction between active compounds suggested a modulator effect of the intestinal microbiota by reducing the number of bacteria that adhere to epithelial cells or by inhibiting their growth.
- Subjects
DECEPTION; BIOLOGICAL models; FUNCTIONAL foods; PREBIOTICS; GUT microbiome; HARM reduction
- Publication
Foods, 2022, Vol 11, Issue 11, p1636
- ISSN
2304-8158
- Publication type
Article
- DOI
10.3390/foods11111636