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- Title
TRIGONELLA FOENUM-GRAECUM (SICKLEFRUIT FENUGREEK) SEEDS - A NATURAL HEPATOPROTECTOR THAT PREVENTS ETHANOL-INDUCED TOXICITY.
- Authors
Rosioru, Corina; Pribac, G.; Simeoni, Iuliana; Craciun, C.; Ardelean, A.
- Abstract
Fenugreek has been used in empirical medicine and as a food additive since ancient times. Lately, its antioxidant and hypoglycemiant properties are intensely studied. This paper reports an investigation of hepatoprotective action of fenugreek seed flour in ethanolintoxicated rats. Animals received ethanol (EtOH) 10% v/v in drinking water, or EtOH and 5% (EtOH+T5%) and 10% (EtOH+T10%) respectively, fenugreek flour (w/w) in a standard diet. After 30 days of treatment, rats were sacrificed, and blood and liver tissue samples were collected for morphological and biochemical assays. The results were compared to values obtained from control animals, and from animals which received EtOH only. Most of the investigated parameters altered by EtOH intoxication were modified by fenugreek seeds in a beneficicial manner. Good effects were obtained especially for WBC count and enzymatic activities (ASAT, ALAT, LDH), and were more concludent with the higher (10%) fenugreek dose. The obtained results are discussed in comparison with data in the litterature.
- Subjects
ETHANOL; ALCOHOLISM; IMMUNITY; AMINOTRANSFERASES; TRIGONELLA; IN vivo toxicity testing; EMPIRICAL medicine; FOOD additives
- Publication
Annals of the Romanian Society for Cell Biology, 2010, Vol 15, Issue 2, p390
- ISSN
2067-3019
- Publication type
Article