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- Title
Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis.
- Authors
Molloy, Síle F; Ross, Brad; Kanyama, Cecilia; Mfinanga, Sayoki; Lesikari, Sokoine; Heyderman, Robert S; Kalata, Newton; Ellis, Jayne; Kouanfack, Charles; Chanda, Duncan; Temfack, Elvis; Lakhi, Shabir; Moodley, Anand; Chan, Adrienne K; Oosterhout, Joep J van; Mapoure, Yacouba; Mwaba, Peter; Lalloo, David G; Wang, Duolao; Lortholary, Olivier
- Abstract
Among 472 patients with human immunodeficiency virus-associated cryptococcal meningitis, 16% had severe visual loss at presentation, and 46% of these were 4-week survivors and remained severely impaired. Baseline cerebrospinal fluid opening pressure ≥40 cmH2O (adjusted odds ratio [aOR], 2.56; 95% confidence interval [CI], 1.36–4.83; P =.02) and fungal burden >6.0 log10 colonies/mL (aOR, 3.01; 95% CI, 1.58–5.7; P =.003) were independently associated with severe visual loss.
- Subjects
INTRACRANIAL pressure; MENINGITIS; IMMUNODEFICIENCY; INTRACRANIAL hypertension; FLUID pressure; CEREBROSPINAL fluid; RETROVIRUSES
- Publication
Open Forum Infectious Diseases, 2021, Vol 8, Issue 4, p1
- ISSN
2328-8957
- Publication type
Article
- DOI
10.1093/ofid/ofab066