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- Title
Rescue of Replication-Competent ZIKV Hidden in Placenta-Derived Mesenchymal Cells Long After the Resolution of the Infection.
- Authors
Bordoni, Veronica; Lalle, Eleonora; Colavita, Francesca; Baiocchini, Andrea; Nardacci, Roberta; Falasca, Laura; Carletti, Fabrizio; Cimini, Eleonora; Bordi, Licia; Kobinger, Gary; D'Ambrosio, Valentina; Natale, Fabio; Giancotti, Antonella; Manganaro, Lucia; Nonno, Franca Del; Zumla, Alimuddin; Liuzzi, Giuseppina; Ippolito, Giuseppe; Capobianchi, Maria Rosaria; Agrati, Chiara
- Abstract
The Zika virus (ZIKV) genome, its negative-strand viral proteins, and virus-like particles were detected in placenta-derived mesenchymal cells (MSCs), indicating that ZIKV persists after virus clearance from maternal blood and can be rescued by in vitro cultivation. We report for the first time the presence of replication-competent ZIKV in MSCs from an asymptomatic woman who acquired infection during pregnancy.
- Subjects
ZIKA virus; VIRAL proteins; VIRUS-like particles; CELLS; INFECTION
- Publication
Open Forum Infectious Diseases, 2019, Vol 6, Issue 10, pN.PAG
- ISSN
2328-8957
- Publication type
Article
- DOI
10.1093/ofid/ofz342