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- Title
The Acute Post-Traumatic Period in Rats Is Accompanied by an Anxiety State and a Decrease in the Proportion of REM Sleep.
- Authors
Komol'tsev, I. G.; Levshina, I. P.; Novikova, M. R.; Tishkina, A. O.; Stepanichev, M. Yu.; Gulyaeva, N. V.
- Abstract
The sequelae of craniocerebral trauma (CCT) were studied using a model based on severe (3-4 atm) lateral hydrodynamic percussion (liquid-percussive brain injury) in male Sprague-Dawley rats. With the aim of detecting the symptoms of anxiety states, the rats' behavior was assessed in the dark-light box and the elevated plus maze test; sleep impairments were detected by recording the electrocorticogram (ECoG) before trauma and during the first week after trauma. The results provided evidence of the post-CCT development of signs of an anxiety state, accompanied by decreases in the proportion of REM sleep and decreases in the amplitude and frequency of the ECoG during this phase.
- Subjects
RAPID eye movement sleep; CRANIOCEREBRAL injuries; MAZE tests; SLEEP; RAT behavior
- Publication
Neuroscience & Behavioral Physiology, 2018, Vol 48, Issue 7, p785
- ISSN
0097-0549
- Publication type
Article
- DOI
10.1007/s11055-018-0631-3