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- Title
The BigBrainWarp toolbox for integration of BigBrain 3D histology with multimodal neuroimaging.
- Authors
Paquola, Casey; Royer, Jessica; Lewis, Lindsay B.; Lepage, Claude; Glatard, Tristan; Wagstyl, Konrad; DeKraker, Jordan; Toussaint, Paule-J.; Valk, Sofie L.; Collins, Louis; Khan, Ali R.; Amunts, Katrin; Evans, Alan C.; Dickscheid, Timo; Bernhardt, Boris
- Abstract
Neuroimaging stands to benefit from emerging ultrahigh-resolution 3D histological atlases of the human brain; the first of which is 'BigBrain'. Here, we review recent methodological advances for the integration of BigBrain with multi-modal neuroimaging and introduce a toolbox, 'BigBrainWarp', that combines these developments. The aim of BigBrainWarp is to simplify work-flows and support the adoption of best practices. This is accomplished with a simple wrapper function that allows users to easily map data between BigBrain and standard MRI spaces. The function automatically pulls specialised transformation procedures, based on ongoing research from a wide collaborative network of researchers. Additionally, the toolbox improves accessibility of histological information through dissemination of ready-to- use cytoarchitectural features. Finally, we demonstrate the utility of BigBrainWarp with three tutorials and discuss the potential of the toolbox to support multi-scale investigations of brain organisation.
- Subjects
HISTOLOGY; BRAIN imaging; INFORMATION dissemination; DATA mapping
- Publication
eLife, 2021, p1
- ISSN
2050-084X
- Publication type
Article
- DOI
10.7554/eLife.70119