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- Title
Model Validation of Breast Cancer Induced to Bone Using 99mTc- MDP.
- Authors
Nasir, Nurnabiha Syifaa; Baharuddin, Nur Saeida; Mansor, Mohd Syahir; Mohamad, Sharlina
- Abstract
Metastasis is a process of tumour cells escaping from the primary site and form a new lesion in other organs. It is a common phenomenon where bone is the frequent metastatic site. Bone scan using 99m-Techetium-Methylenediphosphate (99mTc-MDP) is used to diagnose bone pathologies such as bone metastases. 99mTc-MDP specifically binds to calcium which present in bone. This study aimed to validate 99mTc-MDP in breast cancer-induced to bone rat model and to determine calcium presence in the progression of metastasis. The rats were divided into two groups (normal and cancer-induced groups). For cancer-induced group, the left femur was induced with breast cancer cell line, MDA-MB-231. After 21 days, all rats were subjected to SPECT-CT scan. Our finding suggests that the kidney uptake of 99mTc-MDP is due to the calcium crystal presence caused by hypercalcemia. This is only a preliminary data, and further analysis will be conducted.
- Subjects
BONE cancer; BREAST cancer; MODEL validation; STERNUM; BONE metastasis
- Publication
Malaysian Journal of Medicine & Health Sciences, 2019, Vol 15, p194
- ISSN
1675-8544
- Publication type
Article