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- Title
Dehydroeffusol Rescues Amyloid β<sub>25-35</sub>-Induced Spatial Working Memory Deficit.
- Authors
Fukuda, Toshiyuki; Sato, Yuichi; Takiguchi, Mako; Yamamoto, Takahiro; Murasawa, Hiroyasu; Pawlak, Akiko; Kobayashi, Hiroyuki; Tamano, Haruna; Takeda, Atsushi
- Abstract
Amyloid β (Aβ) peptides produced from the amyloid precursor protein, a transmembrane protein, are neurotoxic and blocking the neurotoxicity may lead to prevention of Alzheimer's disease (AD). Here we tested whether Aβ25-35-induced cognitive decline is rescued by treatment with dehydroeffusol, a phenanthrene isolated from Chinese medicine Juncus effusus. Dehydroeffusol (5 ~ 15 mg/kg body weight) was orally administered to mice for 6 days and Aβ25-35 (2 mM) was injected at the rate of 1 μl/min for 3 min into the lateral ventricle. Y-maze test was performed after dehydroeffusol administration for 12 days. Aβ25-35 impaired learning and memory in the test, while the impairment was dose-dependently rescued by dehydroeffusol administration. The present study indicates that treatment with dehydroeffusol is effective for rescuing Aβ25-35-induced cognitive decline.
- Subjects
AMYLOID beta-protein precursor; SHORT-term memory; MEMBRANE proteins; ALZHEIMER'S disease prevention; CHINESE medicine; JUNCUS effusus; BIOLOGICAL models; ALZHEIMER'S disease; ANIMAL experimentation; HYDROCARBONS; LEARNING; MEMORY disorders; MICE; PEPTIDES; ANIMALS
- Publication
Plant Foods for Human Nutrition, 2020, Vol 75, Issue 2, p279
- ISSN
0921-9668
- Publication type
journal article
- DOI
10.1007/s11130-020-00816-0