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- Title
EXPRESSION LEVEL OF STEROL REGULATORY ELEMENT-BINDING PROTEINS IN A NOVEL RAT MODEL OF METABOLIC SYNDROME.
- Authors
Kudo-Osawa, Makiko; Matsuyama, Mikiko; Noshiro, Mitsuhide; Aoyama, Yuri; Yoshida, Yuzo
- Abstract
1. In the present study, the expression of sterol regulatory element-binding proteins (SREBPs) in livers of a novel rat model of metabolic syndrome, namely SHRSP.Z- Leprfa/IzmDmcr (SHRSP.ZF), as well as its lean littermates (SHRSP.lean), was examined. 2. The expression of SREBP-1c was significantly elevated in SHRSP.ZF rats, whereas expression of SREBP-2 was significantly decreased. 3. Serum cholesterol levels in SHRSP.ZF rats were significantly higher than those in SHRSP.lean rats. 4. Elevation of cholesterol levels by cholesterol loading significantly elevated SREBP-1c levels and significantly decreased SREBP-2 levels in SHRSP.lean rats, suggesting that serum cholesterol levels may be closely related to the expression SREBPs. 5. These results suggest that the expression of SREBP-1c and -2 is modified in the metabolic syndrome rats as a result of the high cholesterol level in these rats.
- Subjects
CHOLESTEROL; METABOLIC syndrome; CARRIER proteins; STEROLS; ANIMAL models in research
- Publication
Clinical & Experimental Pharmacology & Physiology, 2007, Vol 34, pS17
- ISSN
0305-1870
- Publication type
Article
- DOI
10.1111/j.1440-1681.2007.04763.x