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- Title
Gastric Focal Neutrophil Infiltration and Wide Duodenal Gastric Foveolar Metaplasia Are Histologic Discriminative Markers for Crohn's Disease and Behçet's Disease.
- Authors
Akemoto, Yui; Sakuraba, Hirotake; Tanaka, Masanori; Hiraga, Hiroto; Kikuchi, Hidezumi; Morohashi, Satoko; Ota, Shinji; Hasui, Keisuke; Satake, Miwa; Watanabe, Rina; Tanaka, Nahoko; Kawaguchi, Shogo; Tatsuta, Tetsuya; Sawaya, Manabu; Chinda, Daisuke; Mikami, Tatsuya; Ishiguro, Yoh; Kijima, Hiroshi; Fukuda, Shinsaku
- Abstract
Background/Aims: Behçet's disease (BD) with intestinal lesions and Crohn's disease (CD) share clinical features. However, no report has compared the 2 diseases with regard to lesions of the upper gastrointestinal tract (UGT). We aimed to evaluate endoscopic and histologic findings of UGT in CD and BD. Methods: We retrospectively assessed the endoscopic records and biopsy samples of 84 Helicobacter pylori-negative patients (50 CD, 34 BD). In duodenal samples, MUC5AC immunohistochemical analysis was performed to identify gastric foveolar metaplasia. Results: In endoscopic findings, bamboo joint-like appearance (17/50 CD, 0/34 BD) and erosions (14/50 CD, 2/34 BD) were significantly more frequent in CD gastric lesions (p < 0.001, and p = 0.012). In histologic findings of stomach, focal neutrophil infiltration in lamina propria (15/48 CD, 1/34 BD) was significantly more frequent in CD (p < 0.001). In that of duodenum, wide gastric foveolar metaplasia (19/49 CD, 1/34 BD) was significantly more frequent in CD duodenal lesions (p = 0.013). The mean maximum width of the gastric foveolar metaplasia was 114.0 ± 10.6 and 29.5 ± 4.5 μm for CD and BD respectively (p = 0.003). Conclusions: In H. pylori-negative patients, gastric focal neutrophil infiltration and wide duodenal gastric foveolar metaplasia were important for distinguishing CD from BD.
- Subjects
BEHCET'S disease; CROHN'S disease; METAPLASIA; GASTROINTESTINAL system
- Publication
Digestion, 2019, Vol 100, Issue 3, p210
- ISSN
0012-2823
- Publication type
Article
- DOI
10.1159/000494922