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- Title
Special presentation of antiphospholipid syndrome.
- Authors
Couissi, Imane; Soughi, Meryem; El Fid, Kawtar; Douhi, Zakia; El Loudi, Sara; BayBay, Hanane; Mernissi, Fatima Zahra
- Abstract
Antiphospholipid antibody syndrome (APAS) is a condition of acquired thrombophilia due to autoantibodies directed against membrane phospholipids and/or their cofactors. It may be primary or part of a systemic autoimmune disease, such as systemic lupus erythematosus (SLE). Dermatological lesions during APS are frequent, although non-specific, sometimes inaugural, and may be the only clinical manifestation. However, extensive cutaneous necrosis is rare and treatment is based on anticoagulants and appropriate local care. Herein, we report a case of multiple extensive cutaneous necroses in a female with SLE. The particularity of our case is the presence of two types of lesions, necrotizing plaques surmounted by hemorrhagic bullae surrounded by a purpuric border specific to antiphospholipid syndrome and ecchymotic plaques evolving according to the color of the biligenesis, which may be consistent with coagulopathy, in particular, a protein C or S deficiency, hence the interest in good knowledge and semiological analysis.
- Subjects
SYSTEMIC lupus erythematosus; PROTEIN S deficiency; ANTIPHOSPHOLIPID syndrome; PHOSPHOLIPID antibodies; SYMPTOMS; AUTOIMMUNE diseases
- Publication
Our Dermatology Online / Nasza Dermatologia Online, 2023, Vol 14, Issue 4, p420
- ISSN
2081-9390
- Publication type
Article
- DOI
10.7241/ourd.20234.17