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- Title
An age-downregulated ribosomal RpS28 protein variant regulates the muscle proteome.
- Authors
Jianqin Jiao; Kavdia, Kanisha; Pagala, Vishwajeeth; Palmer, Lance; Finkelstein, David; Yiping Fan; Junmin Peng; Demontis, Fabio
- Abstract
Recent evidence indicates that the composition of the ribosome is heterogeneous and that multiple types of specialized ribosomes regulate the synthesis of specific protein subsets. In Drosophila, we find that expression of the ribosomal RpS28 protein variants RpS28a and RpS28-like preferentially occurs in the germline, a tissue resistant to aging and that it significantly declines in skeletal muscle during aging. Muscle-specific overexpression of RpS28a at levels similar to those seen in the germline decreases early mortality and promotes the synthesis of a subset of proteins with known anti-aging roles, some of which have preferential expression in the germline. These findings indicate a contribution of specialized ribosomal proteins to the regulation of the muscle proteome during aging.
- Subjects
RIBOSOMAL proteins; MUSCLE aging; MUSCLE proteins; SKELETAL muscle
- Publication
G3: Genes | Genomes | Genetics, 2021, Vol 11, Issue 7, p1
- ISSN
2160-1836
- Publication type
Article
- DOI
10.1093/g3journal/jkab165