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- Title
Impact of cardiac size on diagnostic performance of single-photon emission computed tomography myocardial perfusion imaging: insights from the REgistry of Fast Myocardial Perfusion Imaging with NExt generation single-photon emission computed tomography.
- Authors
Randazzo, Michael J; Elias, Pierre; Poterucha, Timothy J; Sharir, Tali; Fish, Matthews B; Ruddy, Terrence D; Kaufmann, Philipp A; Sinusas, Albert J; Miller, Edward J; Bateman, Timothy; Dorbala, Sharmila; Carli, Marcelo Di; Castillo, Michelle; Liang, Joanna X; Miller, Robert J H; Dey, Damini; Berman, Daniel S; Slomka, Piotr J; Einstein, Andrew J
- Abstract
Aims Variation in diagnostic performance of single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) has been observed, yet the impact of cardiac size has not been well characterized. We assessed whether low left ventricular volume influences SPECT MPI's ability to detect obstructive coronary artery disease (CAD) and its interaction with age and sex. Methods and results A total of 2066 patients without known CAD (67% male, 64.7 ± 11.2 years) across nine institutions underwent SPECT MPI with solid-state scanners followed by coronary angiography as part of the REgistry of Fast Myocardial Perfusion Imaging with NExt Generation SPECT. Area under receiver-operating characteristic curve (AUC) analyses evaluated the performance of quantitative and visual assessments according to cardiac size [end-diastolic volume (EDV); <20th vs. ≥20th population or sex-specific percentiles], age (<75 vs. ≥75 years), and sex. Significantly decreased performance was observed in patients with low EDV compared with those without (AUC: population 0.72 vs. 0.78, P = 0.03; sex-specific 0.72 vs. 0.79, P = 0.01) and elderly patients compared with younger patients (AUC 0.72 vs. 0.78, P = 0.03), whereas males and females demonstrated similar AUC (0.77 vs. 0.76, P = 0.67). The reduction in accuracy attributed to lower volumes was primarily observed in males (sex-specific threshold: EDV 0.69 vs. 0.79, P = 0.01). Accordingly, a significant decrease in AUC, sensitivity, specificity, and negative predictive value for quantitative and visual assessments was noted in patients with at least two characteristics of low EDV, elderly age, or male sex. Conclusion Detection of CAD with SPECT MPI is negatively impacted by small cardiac size, most notably in elderly and male patients.
- Subjects
HEART anatomy; SINGLE-photon emission computed tomography; RECEIVER operating characteristic curves; RESEARCH funding; HEART function tests; SEX distribution; AGE distribution; CORONARY artery disease; CORONARY angiography; COMPARATIVE studies; SENSITIVITY &; specificity (Statistics)
- Publication
European Heart Journal - Cardiovascular Imaging, 2024, Vol 25, Issue 7, p996
- ISSN
2047-2404
- Publication type
Article
- DOI
10.1093/ehjci/jeae055